Shinji Oikawa Selected Research

Melatonin

3/2015	Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway.
11/2004	Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle.

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Shinji Oikawa Research Topics

Disease

43	Neoplasms (Cancer) 10/2023 - 05/2002
29	Carcinogenesis 01/2024 - 05/2002
16	Inflammation (Inflammations) 01/2020 - 05/2002
12	Leukemia 09/2010 - 08/2002
11	Cholangiocarcinoma 11/2022 - 09/2003
10	Nasopharyngeal Carcinoma 08/2023 - 10/2012
5	Infections 08/2021 - 09/2003
4	Rupture 04/2023 - 06/2009
4	Urinary Bladder Neoplasms (Bladder Cancer) 05/2022 - 10/2011
4	Parkinson Disease (Parkinson's Disease) 11/2018 - 09/2006
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2023 - 09/2012
3	Ischemia 09/2020 - 06/2009
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 06/2003
2	Alzheimer Disease (Alzheimer's Disease) 10/2023 - 03/2017
2	Brain Ischemia (Cerebral Ischemia) 04/2023 - 06/2009
2	Hyperglycemia 02/2023 - 11/2003
2	Virus Diseases (Viral Diseases) 01/2023 - 08/2021
2	Lung Neoplasms (Lung Cancer) 01/2020 - 03/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2018 - 01/2017
2	Hypertrophy 01/2018 - 02/2006
2	Nasopharyngitis 01/2016 - 01/2014
2	Squamous Cell Carcinoma of Head and Neck 01/2015 - 09/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2014 - 09/2011
2	Obesity 01/2014 - 09/2012
2	Neuroblastoma 01/2009 - 07/2008
1	Pathologic Processes 02/2023
1	COVID-19 01/2023
1	Wounds and Injuries (Trauma) 01/2022
1	Coinfection 08/2021
1	Papillomavirus Infections 08/2021
1	Cardiomegaly (Heart Hypertrophy) 11/2020
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2020
1	Colonic Neoplasms (Colon Cancer) 01/2020
1	Ulcerative Colitis 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Disease Progression 11/2018
1	Neoplasm Metastasis (Metastasis) 01/2018
1	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 07/2017

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 03/2023 - 06/2005
18	DNA (Deoxyribonucleic Acid)IBA 05/2022 - 09/2002
16	8-Hydroxy-2'-DeoxyguanosineIBA 12/2013 - 06/2003
11	8-nitroguanineIBA 01/2020 - 09/2003
10	Biomarkers (Surrogate Marker)IBA 07/2020 - 09/2005
9	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2009 - 05/2002
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 05/2002
5	heat-shock protein 70.1IBA 04/2023 - 12/2009
4	CalpainIBA 04/2023 - 06/2009
4	Taurine FDA Link 01/2023 - 12/2018
4	DNA AdductsIBA 05/2022 - 05/2002
4	Oxygen (Dioxygen)IBA 12/2014 - 09/2003
4	MetalsIBA 07/2008 - 05/2002
3	TeaIBA 10/2023 - 08/2003
3	CarcinogensIBA 01/2022 - 08/2003
3	NitrogenIBA 12/2014 - 09/2003
3	Photosensitizing Agents (Photosensitizers)IBA 11/2009 - 02/2003
3	Nucleic AcidsIBA 09/2005 - 09/2003
3	NickelIBA 10/2002 - 05/2002
2	FructoseIBA 01/2024 - 11/2022
2	AntioxidantsIBA 03/2023 - 11/2005
2	CathepsinsIBA 01/2022 - 12/2009
2	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 01/2022 - 08/2003
2	Amino Acids FDA Link 01/2020 - 09/2011
2	IndiumIBA 01/2020 - 03/2018
2	Matrix Metalloproteinases (MMPs)IBA 06/2017 - 02/2006
2	Indicators and Reagents (Reagents)IBA 01/2016 - 09/2010
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2016 - 08/2004
2	MelatoninIBA 03/2015 - 11/2004
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2014 - 04/2012
2	Superoxide DismutaseIBA 12/2013 - 05/2012
2	NeurotoxinsIBA 01/2009 - 07/2008
1	myricetinIBA 10/2023
1	Small Interfering RNA (siRNA)IBA 08/2023
1	IronIBA 08/2023
1	GelsolinIBA 03/2023
1	Beclin-1IBA 01/2023
1	Antiviral Agents (Antivirals)IBA 01/2023
1	molnupiravirIBA 01/2023
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 11/2022
1	RNA (Ribonucleic Acid)IBA 11/2022
1	Coloring Agents (Dyes)IBA 05/2022
1	CopperIBA 05/2022
1	amidaseIBA 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	Macrophage Migration-Inhibitory FactorsIBA 08/2021
1	Epstein-Barr virus encoded RNA 1IBA 08/2021
1	SmokeIBA 11/2020
1	NAD (NADH)IBA 09/2020
1	Sirtuin 2IBA 09/2020
1	collapsin response mediator protein-2IBA 09/2020
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2020
1	Cell-Free Nucleic AcidsIBA 07/2020
1	CateninsIBA 01/2020
1	SodiumIBA 01/2020
1	propylene dichlorideIBA 01/2020
1	Sulfates (Sulfates, Inorganic)IBA 01/2020
1	AzoxymethaneIBA 01/2020
1	naphthaleneIBA 03/2018
1	PeroxiredoxinsIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018

Therapy/Procedure

6	Therapeutics 08/2023 - 09/2005